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7.2.1 Non-monotonic dose-response relationships 7.2.1.1 Mechanistic understanding of NMDR effects Many EEDs exhibit non-monotonic dose-response curves where low-dose exposure produces greater biological effects than high-dose exposure (139)

Novel perspectives on therapeutic modulation of the gut microbiota

It is usually found in the brain and can easily cross the barrier between the blood and the brain

The primary glucose-lowering effect of metformin resides in the gut, not the circulation: results from short-term pharmacokinetic and 12-week dose-ranging studies

However, it cannot completely prevent natural greying caused by ageing or genetics