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Over time, regular caffeine use can lead to tolerance, as the body adjusts to its presence, requiring higher doses to achieve the same stimulating effects

TNF is also found to be interacting with various proteins, forming TNFELAVL1 interaction, TNFGPX3 interaction, ADAM9TNF interaction, TNFADIPOQ interaction, TNFIL6 interaction, TNFGDF15 interaction, TNFNPPA interaction, CASP1TNF interaction, TNFINS interaction, and TNFLEP interaction at high confidence scores (0.7 or 70%) (Figure 3

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Multiple enzymes are responsible for catalysing the addition and removal of acetyl groups, including histone acetyltransferases (HATs) and histone deacetylases (HDACs) respectively