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These results demonstrate that the catalytically inert dehydrogenase domain in NPAC/GLYR1 functions as a scaffold for the proper assembly of epigenetic partners (Fig

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observed ferroptosis in microglia under high-glucose conditions and confirmed that TREM1 exacerbates iron accumulation in T2DM-related microglia via the PERK pathway of ERS, leading to antioxidant inactivation, lipid peroxidation, and significant ROS increase that induces microglial ferroptosis [161]