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Hypoxia decrease expression of cartilage oligomeric matrix protein to promote phenotype switching of pulmonary arterial smooth muscle cells

This was performed using the oxidant-sensitive probe 2,7-dichlorofluorescein diacetate (DCFH-DA)

Also notably, marked acceleration of disease in the transgenic mice (G93A) with CCS overexpression was not observed when the mice had an additional mutation H80G in the SOD1 (G93A) transgene [26]