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This was a small pilot study (6 participants) results are preliminary and require confirmation in larger trials

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Despite the emergence of SARS-COV-2 VOC intensively decreased the effectiveness of current vaccines and neutralizing antibodies 54 , our datasets demonstrated that LSC-Exo retain potent neutralization activity for all variant pseudoviruses examined, efficiently intercepting the D614G and B.1.617.2 (Delta) pseudoviruses entry into the lung of mice

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Under the induction of oxidative stress, a part of HIF-1 is translocated to mitochondria, where it inhibits the respiratory chain by lowering the expression of mtDNA-encoded mRNA that responses to hypoxia, thus preventing the over-production of ROS and resisting oxidative stress