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Kleckner, Zhang et al., 2017)

Purine Metabolism Dysfunctions: Experimental Methods of Detection and Diagnostic Potential

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Several factors exacerbate this imbalance, including concurrent metabolic acidosis , which drives potassium out of cells and into the bloodstream, and the use of medications that impair renal potassium excretion such as ACE inhibitors, ARBs, potassium-sparing diuretics, and certain beta-blockers