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In the non-parametric Mann Whitney U test, eight biomarkers showed a significant difference, in the DCM-induced animals displaying a significant increase in: TG (SMD 16.60, p = 0.0007), BG (SMD 7.54, p = 0.00001), TC (SMD 7.38, p = 0.009), EF% (SMD -4.13, p = 0.00001), NF-KB (SMD 3.13, p = 0.0001), HMGB1 (SMD 3.00, p = 0.0001), FS% (SMD -2.91, p = 0.00001) and HW/BW ratio (SMD 2.31, p = 0.007)

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These results suggest that the highly conserved positively charged residue K200 in GIRK2 supports a dynamic interaction with PIP 2 that decreases the channels open probability in the absence of other modulators (G, ethanol) ( 2 binding site alter the selectivity of GIRK2 for different PIPs (Qiao et al., 2020)

Those include: Anticoagulants , more commonly known as blood thinners, reduce the bodys ability to clot and increase the risk of serious bleeding

Parkinsons Dis 2011:716871