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J Clin Nurs 24

Pharmacognosy Magazine , 11 (Suppl 2), S258S274

GPx catalyzes the reduction of hydroperoxides (e.g., H 2 O 2 ) to H 2 O via the oxidation of reduced glutathione (GSH) to its oxidized form (GSSH): or more generally Glutathione peroxidases exhibit a nonsequential ping-pong mechanism involving an oxidation reaction followed by a reduction step (Weaver and Skouta 2022)