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From a relevant review (Desai et al., 2001), it may be deduced that smoking increases the clearance of oral HAL (via effects including on CYP1A2), especially at doses lower than 0.5 mg/kg/day

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Since tumor cells with certain oncogenic mutations are very sensitive to ferroptosis, triggering ferroptosis may also have significant therapeutic potential for ferroptosis-sensitive tumor cells ( c /GSH/GPX4 axis have been shown to be fatal in host cells