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The high sensitivity to copper ions of the gr mutant and the enhanced tolerance to copper ions of the gr overexpression strain indicated the involvement of gr gene in copper tolerance in A

The glutamate transport inhibitor DL-Threo--Benzyloxyaspartic acid (DL-TBOA) differentially affects SN38- and oxaliplatin-induced death of drug-resistant colorectal cancer cells

The real effect is that less total body water means the alcohol that is absorbed becomes more concentrated elsewhere in the body

Acute complete depletion may rapidly amplify oxidative stress and cell injury, whereas more gradual depletion appears to allow for more selective redox remodeling without overwhelming stress responses, although further studies including comprehensive transcriptomic and epigenomic analyses will be necessary to dissect the differential regulatory networks altered by different modes of GSH depletion

RNA integrity was confirmed on an Agilent 2100 Bioanalyzer