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doi: 10.1038/nrgastro.2017.20 36 NilssonTKBottigerAKHenriquezPSerra MajemL

High-dose or prolonged pyridoxine supplementation can also lead to alterations in other nutrient levels, for example, extended use of large doses has been associated with reduced serum folate concentrations in some reports, which suggests a need to monitor nutritional balance during long-term therapy

Chelated iron exhibits suppressed catalytic activity (lower number of free Fe binding sites, lower catalytic activity) in ROS formation (e.g., by Fenton reaction, see above) and slowing down PD progression

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In cerebral ischemia/reperfusion models, which often mirror radiation-induced damage effects, reducing ACSL4 levels has demonstrated protective effects against ischemic brain damage [45]