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However, polyunsaturated PLs are inherently unstable due to the weak -O-O bond energy of GPL-OOH and readily undergo secondary free radical reactions, giving way to numerous truncated reactive products, including electrophilic oxidatively truncated lipids (epoxy/keto/hydroxy-lipids), or short leaving fragments without the signatures of parental phospholipid identity, such as 4-hydroxynonenal (4-HNE), 4-oxononenal, acrolein and malondialdehyde (MDA) etc [28]

In our study, we found that restriction of cysteine metabolism ( cysB and cysE ) and inhibition of glutathione synthesis ( gshAB ) lead to a decrease in the sensitivity of the gmhA mutant to antibiotics but not to its expected increase

Conversely, challenges persist, particularly regarding the complexity of their synthesis, environmental safety, and potential long-term toxicity [138]

Principal component analysis revealed distinct microbial community structures between the two groups

[DOI] [PubMed] [Google Scholar] 39.Eaton S