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The function of TMAO in causing endoplasmic reticulum (ER) stress and insulin resistance in diabetes is well-documented, with TMAO levels greater in type 2 diabetics

Dixit S, Bernardo A, Walker JM, et al

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Less than 10 % of the body's iron requirements are met through intestinal absorption, with excess iron being excreted via FPN1 (Fig

Liu XF, Hao JL, Xie T, Malik TH, Lu CB, Liu C, Shu C, Lu CW, Zhou DD (2017) Nrf2 as a target for prevention of age-related and diabetic cataracts by against oxidative stress