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In the following sections, we will emphasize the most important impact of exercise on some of the human organ systems related to aging and longevity and, ultimately, discuss the effects of exercise promoting longevity on the human body as a whole (Figure 2)

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Although the general mechanisms of APAP-induced liver injury appear to be very similar in the 2 substrains [132], the risk for experimental design is that there is a mismatch in the substrains between WT and KO mice, which can lead to misinterpretation of the data