glutathione endogenous antioxidant Glutathione: Master Antioxidant, Reducing Oxidative Stress, and Detoxification The use of antioxidants in

Wong F, Gill MA

[16], depletion of GSH by buthionine sulfoximine (BSO), a potent inhibitor of the enzyme gamma-glutamyl-cysteine synthetase, increased susceptibility to cuproptosis in A549 lung cancer cells by suppressing lipoylation and promoting DLAT oligomerization [72]

FSP1 can inhibit ferroptosis by reducing ubiquinone or CoQ to ubiquinone or CoQH 2 on the cell membrane, with the latter functioning as an antioxidant that trap radicals and thus prevents lipid peroxidation, thereby preventing ferroptosis (Fig

Dexrazoxane protects cardiomyocyte from doxorubicin-induced apoptosis by modulating mir-17-5p

( b ) Quantification of IHC staining shown in panel (a) (count of positive cell or fold change of positive area/200field) (n = 5 in each group) (**p = 0.0082, **p = 0.0059, **p = 0.0022, **p = 0.0016)