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This kind of compounds shows a high specificity for IRAP against APN (Compound 8 IC 50 = 5.8 M) and according to docking studies, the inhibitor acts in a binding pocket close to the GAMEN loop without interacting with the zing atom, leading to uncompetitive inhibition, confirmed later on by kinetic studies

Case reports have described thrombocytopenia and altered aggregation, but the condition is rare and the mechanism not fully characterized

Wound healing : Studying connective tissue deposition, angiogenesis, and inflammatory markers in animal models

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In absolute terms, under high immune escape, vaccinating only high-risk groups averted 76,000 hospitalizations (95% CI, 34,000-118,000) and 7,000 deaths (95% CI, 3,000-11,000) versus no recommendation