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Based on our findings, we introduced YK1, a small molecule inhibitor that disrupts the ELF3-MED23 interaction, leading to the transcriptional downregulation of HER2 and KRAS

Gene set enrichment assay (GSEA) GSEA was conducted using the GSEA program provided by the Broad Institute ( All samples from the GSE39582 and GSE87211 datasets were first grouped according to KRAS mutation isotypes and then further subdivided based on HER2 or ELF3 expression levels (top 33%/bottom 33%) to define the phenotypes within the datasets

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The activity of this bean GST was increased 2- to 3-fold by exposing plant cells to an elicitor prepared from cell walls of the fungal bean pathogen Colletotrichum lindemuthianum (Edwards and Dixon, 1991)