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Nevertheless, NRF2 orchestrates the regulation of an extensive array of genes, encompassing not only various families of antioxidant enzymes but also those involved in non-cytochrome P450 phase-I and phase-II drug metabolism

10.1038/sj.bjc.6605954 208 WatanabeT.MitsuhashiM.SagawaM.RiM.SuzukiK.AbeM.et al (2013)

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Methyl transfer reactions convert SAM to S-adenosylhomocysteine (SAH), a potent allosteric inhibitor of methyltransferases (e.g., METTL3)