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This review provides a systematic overview of the latest research advances in drug delivery strategies that penetrate the BBB, conducting an in-depth analysis of the mechanisms, advantages, and challenges of various strategies, and exploring their potential applications in the treatment of NDDs

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Protocol approach: partial rotator cuff tear Goal: Promote tissue healing, prevent tear progression, avoid surgery if possible Peptide approach: BPC-157: 300 to 500 mcg daily, split doses, local injection near shoulder preferred TB-500: 750 to 1000 mcg twice weekly (loading phase first four weeks), then 500 mcg twice weekly GHK-Cu: 300 to 600 mcg daily from week two onward Duration: Twelve weeks minimum Critical notes: Partial tears require imaging to determine severity and location