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[2] [3] It is important to recognise that values below 150 pmol/L are usually considered deficient , whilst results between 150250 pmol/L may indicate borderline or subclinical deficiency

Side effects from B12 supplementation are uncommon but may include: Mild gastrointestinal symptoms such as nausea or diarrhoea, typically with very high oral doses Headache or dizziness in some individuals Skin reactions (rash, itching) at injection sites when using intramuscular preparations Rare but serious allergic reactions, including anaphylaxis with injectable forms Hypokalaemia (low potassium) may occur during rapid correction of severe megaloblastic anaemia If you experience symptoms of a severe allergic reaction (difficulty breathing, severe rash, swelling of face or throat) after taking B12, seek immediate medical attention

Gene expression studies show it activates DNA repair genes and tumor suppressors like p53 while dialing down genes linked to metastasis

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It can also raise blood calcium levels, which can lead to organ damage (21)