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Studies have demonstrated that alpha-lipoic acid can preserve tight junction integrity [231] and reduce neuroinflammation by inhibiting nuclear factor-kappa B (NF-B) signaling, a key pathway involved in the production of pro-inflammatory cytokines [233]

[2] The cationic (unbound) form is red and has an absorption spectrum maximum at 465 nm, whereas the anionic bound form has an absorption spectrum maximum at 595 nm

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Neuropharmacology 56:122132 Castner S, Murthy N, Ridler K, Herdon H, Roberts B, Weinzimmer D, Huang Y, Zheng M, Rabiner E, Gunn R (2014) Relationship between glycine transporter 1 inhibition as measured with positron emission tomography and changes in cognitive performances in nonhuman primates

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