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Description

Dreis, S

Sun et al., 2016b

Almost every tissue in the body contains the GC receptor (GCR) (142)

These findings suggest that FM subjects with high anti-SGC IgG levels have elevated concentrations of BAs compared to those with low anti-SGC IgG levels

Consistent with the reduced in vitro binding, in TFG-depleted HEK293T cells reconstituted with exogenous TFG constructs, both PB1-deleted and CC-deleted TFG failed to support lysosomal CHMP4BmNG recruitment upon LLOMe treatment (Extended Data Fig