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The carboxy-terminal region commonly comprises domains that bind Ca 2+ /CaM complex and inositol (1,4,5)-trisphosphate receptor binding (CIRB), and other molecules, such as trimeric G proteins (Friedlova et al., 2010

First, gene-expression changes in cultured cells exposed to a compound do not, by themselves, establish a systemic therapeutic effect in a living organism, let alone in a human

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