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In addition to regulating SLC7A11 mRNA stability, the m 6 A modification has also been observed to participate in ferroptosis by affecting the mRNA splicing of SLC7A11[163]

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Mechanistically, SPR analysis confirmed that AB4 directly binds to the RAGE V-domain with high affinity (KD = 3.86 M), characterized by rapid association and slow dissociation kinetics

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2.4.2 Cell death Oxidative stress is a major inducer of cardiomyocyte death in MIRI, contributing significantly to the loss of functional myocardium