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Dysesthesia (Skin Sensitivity) A distinct side effect that has emerged primarily at higher doses of retatrutide is dysesthesia an altered, sometimes uncomfortable physical sensation on the skin, often described as mild tingling, burning, or hyper-sensitivity to touch

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this is characterized by a decrease in mitochondrial volume and membrane density, a reduction or disappearance of cristae structures, rupture of the outer membrane, and other morphological changes [21]

G., Boschat, C., Corbaz, A