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Moreover, in the hypothyroid animals, many of the mast cells showed partial or complete degranulation, which was in contrast to the non-activated mast cells in the animals with normal thyroid function.[ref] Other animal studies show that hypothyroidism increases mast cell infiltration into the liver and mast cell levels in the bone marrow

thus, targeting NPY neurons/Y receptors specifically for obesity is not easy and could result in unacceptable side effects

Published: June 12, 2019 Updated: March 11, 2026

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