10.1002/j.1460-2075.1986.tb04350.x [DOI] [PMC free article] [PubMed] [Google Scholar] Chen GF, Fang L, Inouye M
For example, during aging, the levels of O-GlcNAcylated proteins increase, and the O-GlcNAcylation of IKK protein affects NF-B activity 112 , leading to elevated lactate production and glucose consumption 113
Evolving transpeptidase and hydrolytic variants of -glutamyl transpeptidase from Bacillus licheniformis by targeted mutations of conserved residue Arg109 and their biotechnological relevance
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However, factors such as aging, poor diet, stress, and environmental toxins can deplete glutathione levels, leading to oxidative stress and accelerated aging
