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Olaparib, a PARP inhibitor (PARPi), has been demonstrated to not only exacerbate cellular senescence by amplifying DNA damage, upregulating senescence markers (e.g., SA--gal and p21), and inducing irreversible cell cycle arrest, particularly in replicatively senescent macrophages but also trigger mixed apoptotic and necrotic cell death at high doses

FIGURE 2 4.1 Metabolic dysregulation driving mechanisms Hyperglycemia-induced metabolic dysregulation disrupts mitochondrial membrane potential, leading to electron transport chain dysfunction and increased ROS generation (Hedayat et al., 2023)