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While it has not been conclusively established whether this dysfunction is a cause or consequence of the pathological processes, growing evidence suggests that reduced proteasomal activity may contribute to the accumulation of toxic protein aggregates and the progression of neurodegeneration

Bertold C, Fontas E, Singh T, Gastaut N, Ruitort S, Wehrlen Pugliese S, Passeron T

Some patients benefit from diagnostic nerve blocks that temporarily numb specific areas to confirm the pain source

When I dug into their testing claims, things got a little vague

The experiences of functioning and health of patients with primary Sjgrens syndrome: a multicenter qualitative European study