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28 In another study using an Alzheimers model of mice that develop amyloid plaque deposits by 6 months of age, a 30-day oral administration of HEM resulted in fewer plaque deposits in microglia and astrocytes in the cerebral cortex and hippocampus

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Logan S, Pharaoh GA, Marlin MC, Masser DR, Matsuzaki S, Wronowski B, Yeganeh A, Parks EE, Premkumar P, Farley JA, Owen DB, Humphries KM, Kinter M, Freeman WM, Szweda LI, Van Remmen H, Sonntag WE

Sodium valproate decreases biotin absorption, decreases vitamin D metabolism, and decreases availability of folate

After a single cell was defined in each image based on the F-actin staining using the software Fiji (51), the stacks of two-dimensional mitochondrial images were converted into the three-dimensional model by Mitograph 3.0 (30)