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Changes in mitochondrial DNA (MtDNA) in somatic cells are caused by elevated oxidative stress because the mitochondrial genome is very susceptible to mutation (Biniecka et al., 2011a

This approach aligns with recent findings indicating that non-lytic concentrations are essential for accurately determining the bactericidal and bacteriostatic properties of antibiotics while preserving cellular integrity (Kohanski et al., 2007)

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Recent studies have identified multiple potential mechanisms associated with this process (Fig