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[DOI] [PubMed] [Google Scholar] 116.Park S.Y., Pekas E.J., Headid R.J., 3rd, Son W.M., Wooden T.K., Song J., Layec G., Yadav S.K., Mishra P.K., Pipinos I.I

The formation of carbonyl groups within the structure of amino acid side chains can result in protein inactivation and the subsequent accumulation of protein aggregates

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This review systematically dissects the multifaceted roles of cell death in CD across pathogenesis, disease stratification, and treatment response, integrating pre-clinical models, clinical correlations, and therapeutic targets