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[42] showed that Gln supplementation in trauma patients reduces hyperglycemic episodes and improves insulin response

Translational studies using exosomes showed a relationship between the epigenetic modulation of glutamatergic function and a brain metabolic dysfunction known as insulin resistance (IR) as showed by an increase and sex-specific phosphorylation in the expression of IRS1, a key marker of the insulin signaling cascade, in discrete exosomes enriched for the neural cell adhesion molecule L1 (L1CAM), a protein highly expressed in the brain [52, 70,71,72]

doi: 10.1016/j.tibs.2014.02.004 40 kessonKPetterssonSSthlSSurowiecIHedenstrmMEketjllSet al

doi: 10.1159/000334916