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Berthold, M

165 In cancer, FOXOs exhibit dual behavior, either by suppressing tumor growth through autophagy activation or promoting survival under metabolic stress, depending on FOXO localization and the tumor context

It has therefore been proposed that future treatment of gastric motor dysfunctions and related symptoms should be based on identified pathophysiology or actionable biomarkers that is putative mechanisms that are associated with induction of the symptoms suggesting gastroparesis and that can be normalized with specific treatments, such as treatments targeting5-HT 4 , dopamine D 2 and D 3 , and NK 1 receptors

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The DDR regulatory protein p53 transcriptionally activates p21 and its own inhibitor MDM2 37,38,39