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For ethical reasons, animals with large tumor burden were killed

Karin O, Raz M, Tendler A, Bar A, Kohanim YK, Milo T, et al

CXCR4-guided liposomes regulating hypoxic and immunosuppressive microenvironment for sorafenib-resistant tumor treatment

GSH S-conjugates can be considered as tertiary metabolites as opposed to the essential primary metabolites and the secondary ones, which are biosynthesized upon need

Moreover, curcumin enhanced the efficacy of 5-fluorouracil (5-FU) even in cells lacking both p53 and miR-34a/b/c, indicating its potential to improve chemotherapy response in treatment-resistant CRC