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& Baskin, D

Furthermore, HIF-1 signaling promotes glutathione biosynthesis to bolster cellular antioxidant defense capacity, establishing a regulatory feedback loop between oxidative stress and hypoxic adaptation

Advancing Phase II/III clinical trials targeting key nodes of ferroptosis (e.g., iron metabolism, GPX4 function, lipid peroxide clearance) is essential to confirm its therapeutic value and translational potential

Vaccines can be combined with adjuvants, such as drugs like AMG510 (Sotorasib), to create a stronger immune response in the immunosuppressive tumour microenvironment ( Preclinical models in mimic of TNBC Preclinical models that accurately mimic TNBC aetiology are vital for assessing new therapy options and identifying long-term benefits for patients ( in vitro and in vivo ( Figure 10 ) ( Figure 10 Novel breast cancer drugs in use or in clinical trials for the treatment of TNBC Numerous possible agents are undergoing various phases of investigation and advancement

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