chac1 glutathione degradation of enhances cystine-starvation-induced necroptosis and ferroptosis in human triple negative breast cancer cells via the GCN2-eIF2α-ATF4 pathway journal club - Kidney International

journal club Kidney International Frontiers Cysteine Depletion, a Key Action to Challenge Cancer Cells to Ferroptotic Cell Death Glutathione specific gammaglutamylcyclotransferase 1 (CHAC1) increases kidney disease risk by modulating ferroptosis Science Translational Medicine Mammalian proapoptotic factor ChaC1 and its homologues function as glutamyl cyclotransferases acting specifically on glutathione EMBO Reports Springer Nature Link CHAC1: a master regulator of oxidative stress and ferroptosis in human diseases and cancers PMC

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