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When Its Not Just Stress Anymore People rarely walk into a clinic saying, I think my cellular metabolism is off. They say things like: I cant focus the way I used to I feel mentally drained all the time Im not depressed, but Im not myself either Everything just feels harder than it should This is where things get blurred

Recent experimental studies demonstrate that stabilizing mast cells with cromolyn after ischemic stroke reduces peripheral and central inflammation, preserves gut barrier integrity, mitigates dysbiosis, and improves functional outcomes, underscoring the pivotal role of gut-derived mast cells and histamine in post-stroke neuroinflammation (Conesa et al., 2023)

This is a direct consequence of slowed gastric emptying and increased gastrointestinal transit time

Anyway, pro-apoptotic effects were observed in HL60 cells incubated with HOTYR even in conditions not supporting H2O2 accumulation (between 23.8 and 38.0% depending on the media) suggesting that other mechanisms, in addition to the H2O2-releasing activity, could be involved in the pro-apoptotic activity (80)

Development of criteria for cognitive dysfunction in post-COVID syndrome: the IC-CoDi-COVID approach