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juncea GCL shows the locations of these two disulfide bonds (Figure 3B): one disulfide bond (Cys178Cys398) is located at the interface between monomers in the dimer and the second disulfide bond (Cys341Cys356) anchors a -hairpin at the active site entrance (Hothorn et al., 2006)

In this respect, selenosugars seem to be more feasible candidates, since they might exploit glucose- or other transporters ( + is unlikely to be either effectively transported to the brain due to its positive charge and missing capability of effective metabolization in the brain tissue (Suzuki et al., 2006

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Heit JA, Silverstein MD, Mohr DN, Petterson TM, O'Fallon W, Melton L, Iii