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Erratum in: Nat Rev Dis Primers

What is a skinny shot

Int Immunopharmacol 146:113801

Several biomarkers, such as GPX4 and p53, have been identified for their regulatory effect on ferroptosis, and some compounds targeting these molecules to induce ferroptosis have already been found [9, 10]

In the senescent state, FOXO4 accumulates in PML (promyelocytic leukemia) nuclear bodies where it binds and sequesters p53, preventing p53 from activating the mitochondrial apoptotic pathway