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Dexamethasone-loaded biopolymer-lipid hybrid microcarriers have been developed for inner ear delivery and sustained release (Dindelegan et al., 2022)

Nanomedicine: Nanotechnology, Biol

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So in ALS, rather than driving pathology, the baseline microbiome might be trying to counteract it, and losing key microbes removes that brake on microglial activation

Notably, high-dose Rb resulted in stronger enrichment of glutamate and GSH pathways, implying impaired antioxidant defense