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NNMT inhibition increases cellular concentrations of both substrates that the enzyme would otherwise consume: SAM (the universal methyl donor) and nicotinamide (the NAD + salvage precursor)

[70] found that degenerative NP cells exhibited differential expression of lncRNAs and mRNAs, and subsequently explored the relationship between ADMSCs and NP cells in this co-culture system at the gene expression level

M1 macrophages exhibit a proinflammatory phenotype characterized by increased glycolysis and impaired mitochondrial OXPHOS

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Tucker SL, Mohan R , Liengsawangwong R, Martel MK, Liao Z