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Changes in toll-like receptor (TLR)4-NFB-IL1 signaling in male gout patients might be involved in the pathogenesis of primary gouty arthritis

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GSH biosynthesis begins with the production of -glutamylcysteine from glutamate and cysteine in a process catalyzed by -glutamylcysteine synthase (GCLC) [69]

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Single-cell sequencing and spatial multiomics analyses have revealed that Gpx3, which can serve as an important target for metabolic disorders in kidney diseases, is highly expressed in fibroblasts [121]

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