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Abnormal levels of tryptophan can therefore negatively impact immune responses, metabolic stress pathways, and brain function, leading to a wide range of symptoms associated with ME/CFS and FM (Gostner et al., 2020)

Zi-Bin Tian, Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong Province, China

Acta Anaesthesiol Scand 53:717723 Ametov A, Barinov A, Dyck P, Hermann R, Kozlova N, Litchy WJ, Low PA, Nehrdich D, Novosadova M, O'Brien PC, Reljanovic M, Samigullin R, Schuette K, Strokov I, Tritschler HJ, Wessel K, Yakhno N, Ziegler D, SYDNEY Trial Study Group (2003) The sensory symptoms of diabetic polyneuropathy are improved with alpha-lipoic acid: the SYDNEY trial