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This modification significantly enhances its affinity for IGF-1 receptors and resistance to binding proteins, making IGF-1 DES particularly valuable for in-depth studies of cellular proliferation, differentiation, receptor dynamics, and IGF signalling pathways (Wikipedia: IGF-1)

Atoms represented in thick sticks were included in the high layer (QM level), while the rest were treated at the MM level

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Adrenocorticotropic hormone, melanocyte-stimulating hormone, and the melanocortin receptors: revisiting the work of Robert Schwyzer: a thirty-year retrospective