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Mol Syst Biol (2013) 9:712

Fundakowski CE, Hales NW, Agrawal N, Barczynski M, Camacho PM, Hartl DM, Kandil E, Liddy WE, McKenzie TJ, Morris JC, Ridge JA, Schneider R, Serpell J, Sinclair CF, Snyder SK, Terris DJ, Tuttle RM, Wu CW, Wong RJ, Zafereo ME , Randolph GW

found that the differentiation of PC-12 cells (neurons) involves an increase in intracellular copper (Chakraborty et al., 2022)

Importantly, inhibition of baseline Notch signaling in fully transformed human cell lines did not alter sensitivity to GPX4 inhibition, further supporting the conclusion that Notch activation at tumor inception forces an astrocytic developmental trajectory with altered mitochondrial activity but Notch activation later in tumor development is not sufficient to induce similar cell states, metabolic programs, or therapeutic vulnerabilities