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Fibrosis is caused mainly by the overactivation of cardiac fibroblasts, which results in the production of excessive extracellular matrix (ECM) components

Naunyn-Schmiedeberg's Arch Pharmacol 399 , 1465914676 (2026)

Further research, including clinical trials, is needed to establish the effectiveness of these drugs in reducing renal tubular apoptosis and their effect on overall kidney function and disease progression

Moreover, GSNO at this concentration was non-toxic to HUVECs, the first cells exposed to GSNO-derived NO during retrograde perfusion, supporting its safety and endothelial tolerance in this experimental setting