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303 Under normal conditions, SIRT3 levels are high in the brain but decrease in the frontal cortex of AD patients

However, it also suggests that pre-organization of the linker still needs to be optimized by further rigidification to contribute to an efficient covalent reaction

While significant challenges remain, the convergence of advanced molecular tools, improved animal models, and innovative clinical trial designs holds considerable promise for developing effective microglia-targeted therapies in the coming years

RBBP6-Mediated ERR Degradation Contributes to Mitochondrial Injury in Renal Tubular Cells in Diabetic Kidney Disease