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This hypothesis is supported by observed increases in prolactin levels among DFP-treated patients, suggesting a reduced dopaminergic activity (Devos et al., 2022)

While the design of the study was suboptimal, there were no statistically significant drug-related increases in tumor incidences at exposures up to 6-times (males) and 8-times (females) higher than human exposure at the MRHD based on AUC

At these time points, alamarBlue (Sigma-Aldrich) was added at 0.4% concentration and incubated for 2 h (37 C and 5% CO 2 )

The mechanisms involved are unknown at the moment and require extensive further study