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One clinical series found pain relief in 7 of 12 patients after a single intraarticular knee injection [4]

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Deliberately increase fluid consumption to compensate

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Sikiric P, Skrtic A, Gojkovic S, Krezic I, Zizek H, Lovric E, Sikiric S, Knezevic M, Strbe S, Milavic M, Kokot A, Blagaic AB, Seiwerth S

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Macrophages, upon activation by Th1 cells, release various cytokines and inflammatory molecules, including TNF-, proteases, NO, and oxygen-free radicals, causing myelin damage [264]

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